Extended Data Fig. 9: Characterization of Pkm2−/− mice.
From: Metabolic reprogramming by the S-nitroso-CoA reductase system protects against kidney injury
a, Schema illustrating generation of renal epithelial cell-specific Pkm2−/− mice. b, Survival curve following I/R-induced AKI (23 wild-type mice; 20 Pkm2−/− mice). Survival was analysed using Kaplan–Meier estimation. Gehan–Breslow–Wilcoxon test was used to detect significance. c, PEP in injured kidneys from wild-type and Pkm2−/− mice (n = 6 mice per group); injury induced by I/R. d, Pyruvate in injured kidneys from wild-type and Pkm2−/− mice (n = 6 mice per group). Results in c, d are presented as mean ± s.d. Two-tailed Student’s t-test was used to detect significance.
