Extended Data Fig. 6: Effect of CA2 silencing on aggression attack parameters.
From: A circuit from hippocampal CA2 to lateral septum disinhibits social aggression
Amigo2-Cre (Cre) mice and wild-type littermates (WT) were injected into dCA2 with rAAV2-hsyn-DIO-HA-hM4D(Gi)-IRES-mCitrine (AAV-DIO-iDREADD). After 3 weeks, mice were injected intraperitoneally with CNO or saline and, 30 min later, subjected to the resident–intruder test. a–d, Mean (± s.e.m.) number of bites (a), number of attack bouts (b), attack duration (c) and number of tail rattles (d). Grey dots, individual mice (29, 29, 43 and 34 mice from left to right for all bar graphs). Two-sided Mann–Whitney tests: *P = 0.011; **P = 0.096; *P = 0.012; and *P = 0.041, for a–d, respectively.
