Extended Data Fig. 12: Neuromodulation of the CA2-LS synapse by AVP.
From: A circuit from hippocampal CA2 to lateral septum disinhibits social aggression
a, ChR2 expression in dCA2 pyramidal neurons. b, Paired-pulse ratios (right) of PSP amplitudes evoked by two light pulses separated by 50 ms (left), before and after 100 nM AVP (19 cells from 10 mice). Black dots, individual cells; red dots, mean ± s.e.m. Two-sided Wilcoxon test, ****P < 0.0001. Scale bars, 2 mV, 100 ms. c, Example time course of PSPs in dLS evoked by photostimulation of ChR2-expressing dCA2 projections. Grey bar shows period of bath application of 250 nM TGOT. d, PSP amplitudes before and 30 min after application of 250 nM TGOT (7 cells from 3 mice). Black dots, individual cells; red dots, mean ± s.e.m. Two-sided Wilcoxon test, P = 0.3.
