Extended Data Fig. 8: Long-range interactions in homogeneous OSN subpopulations.

a–c, Circos plots representing the 1,000 strongest trans contacts in OLFR16⁺ (a), OLFR17⁺ (b) and OLFR1507⁺ (c) OSNs. d, Left, comparison of the frequency of local cis (grey), long-range cis (blue) and trans (red) Greek island interactions in mixed mOSNs and OSNs expressing specific OR genes. Right, mean values for OLFR16⁺, OLFR17⁺ and OLFR1507⁺ cells are not significantly different from those for mixed mOSNs (P > 0.05 for all comparisons, two-tailed paired Wilcoxon signed-rank test). e, In situ Hi-C contact matrices from OLFR16⁺, OLFR17⁺ and OLFR1507⁺ cells focused on the Olfr16 gene locus. Arrowhead points to specific long-range contacts between Olfr16 and the Greek island Astypalea that occur only in OLFR16⁺ cells. Grey arrowheads mark Greek island–Greek island contacts that also differ between cell types. f, g, Similar analysis for the Olfr16 locus in OLFR17⁺ and OLFR1507⁺ cells. h–j, As in e–g, but for the Olfr17 locus. k–m, As in e–g, but for the Olfr1507 locus.