Extended Data Fig. 6: ATQ exposure via a netting substrate completely inhibits P. falciparum development.
From: Exposing Anopheles mosquitoes to antimalarials blocks Plasmodium parasite transmission
A. gambiae female mosquitoes were allowed to rest for 60 min on 100-denier polyester netting that had been treated with either a 0.5 mg ml−1 (0.05% w/v) solution of ATQ in acetone, or acetone alone. Females exposed to ATQ in this way failed to become infected after an infectious P. falciparum blood meal, demonstrating that a netting substrate is also capable of delivering sufficiently high doses of ATQ to inhibit infection (two-sided chi-squared test, n = 98, df = 1, χ2 = 75.55, P < 0.0001). ****P < 0.0001. Medians are indicated; n denotes the number of biologically independent mosquito samples.
