Extended Data Fig. 2: Model structure and population parameters.
From: Exposing Anopheles mosquitoes to antimalarials blocks Plasmodium parasite transmission
a, Schematic of the mosquito life cycle model with the time step of one day. Mosquitoes spend three days as eggs (Ei) and ten days as larvae (Li) (which includes the pupal stage). Adult female mosquito compartments fall within the dashed box, and begin with a rest day (R0) followed by mating (M) or feeding (F). After feeding, female mosquitoes undergo two days of rest (Ri), followed by a day for egg laying (EL). Then, the cycle repeats. Shaded boxes denote when exposure to insecticide or ATQ could occur. These are the same compartments in which mosquitoes can become infected or transmit infections, assuming they have been infected for a period longer than the incubation time. b, Survival of the mosquito population as a function of age. The curve is a Gompertz distribution with scale parameter b = 0.1868 and shape parameter η = 0.0293. c, Functions relating infection levels of humans and mosquito to risk of infection. Subpanel (i) shows the risk of a human becoming infected, βH, as a function of the number of infectious feeders, f. Subpanel (ii) shows the risk of a mosquito becoming infected, βM, as a function of the fraction of the human population that is infected, IH.
