Extended Data Fig. 5: Testing additional compounds for fitness costs and transmission-blocking activity through tarsal contact.
From: Exposing Anopheles mosquitoes to antimalarials blocks Plasmodium parasite transmission
a, Mosquito survival relative to an untreated control 48 h after exposure to ATQ, DEC, PYR, HYD, ACE and PER. The proportion of female A. gambiae surviving exposure to each compound (1 mmol per m2, 60 min) relative to the proportion of individuals surviving exposure to an untreated control is shown. PER exposure causes almost complete mortality (proportionate survival relative to controls = 0.055, pairwise two-sided chi-squared test with Bonferroni correction, n = 80, df = 1, χ2 = 76.10, P < 0.0001), whereas all other compounds behave comparably to controls. b, Neither PYR nor DEC (1 mmol per m2, 6 min) are capable of reducing the prevalence of P. falciparum through tarsal contact, relative to controls (pairwise two-sided chi-squared test with Bonferroni correction: DEC, n = 93, df = 1, χ2 = 2.42, P = 0.12; PYR, n = 92, df = 1, χ2 = 0.55, P = 0.46). Similarly, DEC and PYR had no effect on the intensity of infection, compared to a mock-treated control (Wilcoxon with Dunn’s post hoc test, n = 183, df = 3, P = 0.31 (DEC) and P = 0.99 (PYR)). Letters indicate groups that are statistically different from one another. ****P < 0.0001. Medians are indicated; n denotes the number of biologically independent mosquito samples.
