Extended Data Fig. 6: Overexpression of PSMD9 in C57BL/6J and DBA/2J mice.
From: An integrative systems genetic analysis of mammalian lipid metabolism
Adenoviral overexpression of PSMD9 in C57BL/6J and DBA/2J mice (n = 9, 7 days after tail-vein injection of 109 plaque-forming units). a, b, Western blot (a) and densitometry (b) of PSMD9 and PDI (loading control) in the livers of mice treated with either control adenovirus (pAdV) or PSMD9 adenovirus. Data are mean ± s.e.m. c, Liver and plasma lipidomics of adenovirus-treated mice. Top panel (above first dotted line) shows relative fold change of total lipid classes. Middle and bottom panels show relative fold changes of individual diacylglycerol and triacylglycerol lipid species, respectively. P values determined by t-test with permutation-based FDR correction. Filled bubbles are significant (q < 0.05) changes, larger bubbles indicate greater significance.
