Extended Data Fig. 4: Correlation network analysis of the HMDP liver proteome.
From: An integrative systems genetic analysis of mammalian lipid metabolism
a, Protein:protein (P:P) correlations in the HMDP liver proteome, integrated with CORUM-annotated proteins and protein interactions previously identified by AP–MS. Numbers indicate CORUM accessions, orange lines are HMDP P:P correlations; purple lines are correlations observed in both HMDP and CORUM. b–e, P:P correlations of selected CORUM complexes including associations not previously identified by AP–MS (green lines). Biweight midcorrelation analyses performed using ranked Benjamin–Hochberg multiple comparison test. Purple lines are known CORUM interactions, orange lines are HMDP P:P and CORUM interactions, green lines are previously unidentified interactions from HMDP P:P data. A thicker line represents a higher bicor value (q < 0.05, n > 50 strains).
