Extended Data Fig. 5: Structural and functional analysis of H1 domain. | Nature

Extended Data Fig. 5: Structural and functional analysis of H1 domain.

From: Structural basis for KCTD-mediated rapid desensitization of GABAB signalling

Extended Data Fig. 5: Structural and functional analysis of H1 domain.The alternative text for this image may have been generated using AI.

a, Ribbon representation of the KCTD12H1 domain. The NFLEQ motif, which is important for desensitization, is coloured orange. b, Ribbon representation and topology map of the KCTD12 H1 monomer. Elements of the secondary structure are labelled. c, Ribbon representation of two KCTD12H1 subunits (green and cyan) and Gβ1γ2. d, Subcellular localization of eGFP–KCTD12(R232D) and eGFP–KCTD12(R257D) mutants with or without GABAB receptor.

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