Extended Data Fig. 1: Comparative analysis of the stm and ngn gene clusters.
From: Enzyme-catalysed [6+4] cycloadditions in the biosynthesis of natural products
a, Structure of streptoseomycin (1) and structurally related natural products nargenicin (2), coloradocin, nodusmicin and branimycin. b, The stm gene cluster from S. seoulensis A01 and the ngn gene cluster from N. argentinensis ATCC 31306. c, Proposed biosynthetic pathway for 1. d, Proposed biosynthetic pathway for 2.
