Extended Data Fig. 7: Components of immune-evasion mechanisms in NSCLC.
From: Neoantigen-directed immune escape in lung cancer evolution
a, Each of the potential immune-evasion mechanisms explored in Fig. 4 are shown, divided into their component genes. Patients are split according to their immune-evasion capacity status. Copy-number losses are shown in blue, and mutations are shown in green. b, A schematic of how LOH of the HLA-C locus in HLA-C1 and HLA-C2 heterozygous tumours may lead to destruction mediated by natural killer cells is shown. c, The level of natural killer cell infiltration divided by the total TIL estimate (using the method of Danaher et al.11) is shown for tumour regions with (n = 45) and without (n = 90) HLA-C LOH, according to their HLA-C1 and HLC-C2 heterozygosity status. A two-sided Wilcoxon rank-sum test is used for comparison.
