Extended Data Fig. 4: Prediction of tumour neoantigens according to mutational processes.

Scatter plots of the fraction of mutations classified as neoantigens against the number of neoantigens for neoantigens with predicted binding affinity <100 nM (left) and neoantigens with predicted binding affinity <500 nM (right). Above and to the right of the scatter plots are the kernel density plots of the number and fraction of neoantigens, respectively. Each dot represents a sample and is colour-coded according to mutational signature and/or clinical subgroup (see Methods).