Extended Data Fig. 7: cPCDH zippers from the γB4EC1–6 crystal structure match the ordered linear arrays observed for γB6EC1–6 on membranes.
From: Visualization of clustered protocadherin neuronal self-recognition complexes
a, Tomographic slice through a reconstructed tomogram of adherent γB6EC1–6-coated liposomes. The region of tomographic slices that is shown in close-up views in c and d is highlighted by an orange box. b, Molecular surface views of the γB4EC1–6 crystal lattice arrangement in three orientations. Each protomer is coloured in a different colour. c, Tomographic slices spanning 143 Å into the depth of the tomogram, one linear array that progresses into the plane of the tomogram is indicated by cyan arrowheads. Grey arrowheads indicate lipid bilayers. d, Crystallographic γB4EC1–6 zipper consisting of five consecutive cis dimers placed into the cryo-ET density of the marked γB6EC1–6 array (cyan arrowheads) observed between membranes. Compare the density and structure fit between c and d. Protomers coloured as in b. Scale bars, 350 Å.
