Extended Data Fig. 5: Electron microscopy density for selected regions of the ACLY structure.
From: An allosteric mechanism for potent inhibition of human ATP-citrate lyase
a, Cryo-EM 3D map of the ACLY tetramer, coloured according to Fig. 1a. b, Electron microscopy density map for a helix in the C-terminal CCLY domain. c, Electron microscopy density of the linker between N-terminal and C-terminal segments (residues 818–830). d, Cryo-EM 3D map of the ACLY N-terminal segment, coloured according to Fig. 1a. e, Electron microscopy density for the β-sheet in the citrate domain. f, Electron microscopy density map for ADP and surrounding residues in the ATP-grasp domain.
