Extended Data Fig. 9: Long-term expression of miR-199a induces progressive cardiac regeneration.
From: MicroRNA therapy stimulates uncontrolled cardiac repair after myocardial infarction in pigs
a, The LGE-cMRI images (from apex to base, a–e) are the same as those in Fig. 4a, but without red counterstain. The red arrows show the infarcted area in the central plane c. b, cMRI images from a pig euthanized at week 8 after MI and AAV6-miR-199a treatment. Top, serial images from apex to base at day 2, week 4 and week 8; the infarct area is counterstained in red. Bottom, the same images without counterstaining. The green arrows show the pacemaker-lead attachment sites. c, Gross anatomy of cardiac slices of the pig shown in b after euthanization. The syringe indicates the injected area. The green arrows show the pacemaker-lead attachment sites. Similar cardiac repair results were observed in three pigs treated with miR-199a that survived two months after treatment.
