Extended Data Fig. 4: miR-199a improves global heart function and decreases infarct mass one month after treatment.
From: MicroRNA therapy stimulates uncontrolled cardiac repair after myocardial infarction in pigs
a, Graphs showing percentage changes in infarct mass, infarct mass over LV mass and ejection fraction, as indicated, between 2 and 28 days after MI and AAV6-control or AAV6-miR-199a delivery, measured by cMRI. The number of analysed animals were 7 and 8, 7 and 8, and 7 and 9 for infarct mass, infarct mass over LV mass and ejection fraction for the two groups, respectively. Top graphs, cumulative values for all pigs. Data are mean ± s.e.m.; *P < 0.05; two-tailed t-test; bottom graphs, data from individual pigs. b, Infarct healing one month after AAV6-miR-199a injection. The LGE-cMRI images (from apex to base, a to e) are the same as in Fig. 1h, but without red counterstain. The red arrows show the infarcted area in the central plane. c, Gross anatomy of cardiac slices with corresponding LGE-cMRI images in representative AAV6-control- and AAV6-miR-199a-treated pig hearts, at 28 days after MI. d, Heart rate in sham and infarcted animals injected with AAV6-control and AAV6-miR-199a at one month after treatment. Data are mean ± s.e.m.; the number of animals per group and time point are indicated.
