Extended Data Fig. 5: AAV6-miR-199a induces cardiomyocyte proliferation in vivo.
From: MicroRNA therapy stimulates uncontrolled cardiac repair after myocardial infarction in pigs
a, Representative images of Ki67 and α-actinin immunofluorescence staining of the infarct border (sector H) or remote (sector L) zones of AAV6-control- and AAV6-miR-199a-treated animals (n = 4 and n = 6, respectively; analysis is from at least seven high-resolution images acquired from at least eight different regions of each heart), 12 days after MI. Scale bars, 100 µm. At least six animals were treated. b, High-magnification, representative images of phospho-histone H3 immunostaining in the infarct border zones of four different pigs treated with AAV6-miR-199a, 12 days after MI. Scale bar, 100 µm.
