Extended Data Fig. 6: Clone size distributions based on simulation using the cell-repositioning model.
a, Total number of intestinal villi over time (purple, same as Extended Data Fig. 4a) normalized against the fitted trend for the villi formation rate (green line), which we use in the numerical simulations. Samples from three mice were analysed per time point. Data are mean ± s.e.m. b, Cumulative distribution of clone sizes (induced at E16.5) at P0 in the LGR5 (red) compared to the KRT19 (blue) tracing (also depicted in Fig. 2d). c, Cumulative distribution of clone sizes (induced at E16.5) at P5 in the LGR5 (red) compared to the KRT19 (blue) tracing also depicted in Fig. 2d. d, Comparison between experimental (dots) and theoretical cumulative distribution of LGR5 clone sizes (induced at E16.5) at P0 (purple), P5 (red) and P11 (cyan). e, Comparison between experimental (dots) and theoretical cumulative distribution of KRT19 clone sizes (induced at E16.5) at P0 (purple), P5 (red) and P11 (cyan). For all panels, clone size was inferred from clonal volume (Supplementary Table 2), using average single-cell measurements of volume as a conversion factor.
