Extended Data Fig. 6: Subclonal genetic evolutionary dynamics in the discovery cohort.
From: Growth dynamics in naturally progressing chronic lymphocytic leukaemia
a, Subclonal dynamics for each patient in the discovery cohort in relation to tumour load over time in the observed disease course (represented by WBC, with dots indicating an available WBC measurement). Arrows denote time of sampling with WES. Distinguishable subclones meeting the criteria for confident detection (>10% CCF, in at least one sequenced sample) are coloured. CCFs in time periods between sequenced time points were inferred from the closest sequenced sample. b, Subclonal growth patterns of additional patients analogous to Fig. 4.
