Extended Data Fig. 3: Clonal shifts and growth rates in untreated CLL patients.
From: Growth dynamics in naturally progressing chronic lymphocytic leukaemia
a, The increase in the numbers of total (top), clonal (middle) and subclonal (bottom) drivers is associated with overall leukaemia growth patterns. P values were determined by Kruskal–Wallis test. b, A trend towards increased maximal change in the CCF of a driver event is observed between the first and last pre-treatment samples of a given patient based on growth pattern. P values were determined by Kruskal–Wallis test. c, Top, probability of having a carrying capacity K of WBC of less than 1,000 × 109 cells per litre (blue dots) for patients with logistic, indeterminate or exponential growth patterns. Bottom, growth rates (small circles) together with 70% credible intervals (lines) across the discovery and extension samples, ordered based on the probability of logistic growth with samples classified as displaying logistic, indeterminate or exponential growth.
