Extended Data Fig. 8: FTY720 treatment has no effect on circulating antibody levels.
From: Migrant memory B cells secrete luminal antibody in the vagina
C57BL/6 mice were infected vaginally with TK− HSV-2. Six weeks later, immunized mice were given drinking water containing 4 μg ml−1 of FTY720. Two weeks later, FTY720-treated mice were challenged intravaginally with wild-type HSV-2 (104 pfu). At the indicated days after challenge, HSV-2-specific antibodies (a) and total antibodies (b) in the blood were measured by ELISA. Sample dilution for virus-specific antibody ELISA was 1:140. Data are mean ± s.e.m. Data are representative of two independent experiments with 3 mice per group.
