Extended Data Fig. 3: B cells do not establish residency in the upper reproductive tract following immunization and challenge with HSV-2. | Nature

Extended Data Fig. 3: B cells do not establish residency in the upper reproductive tract following immunization and challenge with HSV-2.

From: Migrant memory B cells secrete luminal antibody in the vagina

Extended Data Fig. 3

C57BL/6 mice were immunized intravaginally with TK− HSV-2. Five weeks later, mice were challenged with intravaginal wild-type HSV-2. One day after challenge, the number of CD138+CD19+, CD138+CD19− and CD138−CD19+ cells in cervix and uterus was analysed by flow cytometry (naive, n = 4 mice; immune, n = 6 mice; immune and wild-type HSV-2, n = 6 mice). Data are mean ± s.e.m. Data are pooled from two independent experiments. Statistical significance was analysed by two-tailed Mann–Whitney U test.

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