Extended Data Fig. 6: Comparison of the binding sites of different SMO ligands.
From: Cryo-EM structure of oxysterol-bound human Smoothened coupled to a heterotrimeric Gi
a, SAG1.5-bound hSMO (PDB 4QIN). b, Cyclopamine-bound hSMO (PDB 4O9R). c, Vismodegib-bound hSMO (PDB 5L7I). d, SANT1-bound hSMO (PDB 4N4W). e, LY2940680-bound hSMO (PDB 4JKV). In a–e, structures of hSMO with different ligands are viewed from the side of the membrane. f, Superimposition of the ligands that bind the pocket in the transmembrane domain of hSMO.
