Extended Data Fig. 9: Comparison of the Gi-coupled hSMO, inactive hSMO and apo human FZD4.
From: Cryo-EM structure of oxysterol-bound human Smoothened coupled to a heterotrimeric Gi
The Gi-coupled hSMO is in blue, the inactive hSMO is in pink (PDB 5L7D) and apo human FZD4 is in yellow (PDB 6BD4). Structures are viewed from the side of the membrane.
