Extended Data Fig. 1: Structure-based sequence alignment of class-A GPCRs.
From: Conformational transitions of a neurotensin receptor 1–Gi1 complex
The sequences shown are those are for hNTSR1, rNTSR1, mouse μOR, human cannabinoid receptor 1 (CB1), human rhodopsin, human 5-hydroxytryptamine receptor 1B (5HT1B), human A1 adenosine receptor (A1AR), human β2AR and human A2 adenosine receptor (A2AR). The sequence alignment was created using GPCRdb (http://www.gpcrdb.org) and ESPript 373 servers. Secondary structure elements for hNTSR1 are shown as coils and arrows. PIF, PAF, PLF or LVF, DRY or ERY, and NPXXY motifs are highlighted in green, red and blue, respectively. The truncated sequences of hNTSR1(∆ICL3) are highlighted in grey.
