Extended Data Fig. 8: PIEZO1 recognition of cyclical force drives a HIF1α proinflammatory program.
From: Mechanosensation of cyclical force by PIEZO1 is essential for innate immunity
Cyclical force signals via PIEZO1 in myeloid cells, resulting in Ca2+ influx and AP-1-induced EDN1 expression. Ednrb signalling then drives HIF1α stabilization and proinflammatory transcriptional upregulation.
