Extended Data Fig. 8: Cardiotoxicity, inflammation and immune assessments after FAP CAR T cell transfer.
a, Volcano plot showing the differential expression of genes known to be modified in cardiotoxicity in the hearts of mice treated with either AngII/PE and FAP CAR T cells or a saline control for 4 weeks. Statistically significant changes are marked to indicate whether genes are expected to increase (orange) or decrease (blue) in the setting of cardiotoxicity. b, Differential expression of the same conditions in a at 8 weeks. a, b, Two-sided Welch’s t-test; n = 3 biologically independent mice per condition. c, Volcano plot showing the differential expression of 1,659 immune- and inflammation-related genes from hearts of mice treated with AngII/PE and FAP CAR T cells or AngII/PE for 4 weeks. In total, 22 genes were differentially expressed between the conditions. n = 3 mice per condition. d, Photomicrographs and quantification (mean ± s.e.m.) of immune cell (arrowheads) residency of the left ventricle at 4 weeks after either AngII/PE or AngII/PE and FAP CAR T cell treatment. Two-tailed unpaired Student’s t-test; n = 3 or 4 biologically independent mice, respectively. Scale bars, 100 μm.
