Extended Data Fig. 1: Cardiac fibrosis and hypertrophy.
a, Picro-Sirius red staining for cardiac fibrosis (red) in a coronal section of the heart of a PostnMCM;RosaOVA mouse treated with AngII/PE and tamoxifen for 1 week (left). High-powered field of the left ventricular free wall (right). Representative image of three biologically independent mice, showing similar results. Scale bars, 100 μm. b, Control and experimental hearts were measured (weight (mg)) and images captured. Representative images are shown. c, Quantification of heart weight to body weight (HW/BW) ratio of indicated genotypes and conditions. Data are mean ± s.e.m. ****P < 0.0001 (one-way ANOVA between groups, P < 0.0001; post hoc test for multiple comparisons, Tukey’s test; n = 10, 7, 6, 8 biologically independent mice from left to right).
