Extended Data Fig. 3: Peptide and fragment-ion coverage of AMELX isoform 1 and isoform 2 from specimen Dm.M6/7.II.296–16856.
From: Early Pleistocene enamel proteome from Dmanisi resolves Stephanorhinus phylogeny
Peptides specific to AMELX isoform 1 and isoform 2 appear in the top and bottom parts of the figure, respectively. No AMELX isoform 2 is currently reported in public databases for the Cervidae group. Accordingly, the AMELX-isoform-2-specific peptides were identified by MaxQuant spectral matching against bovine (Bos taurus) AMELX isoform 2 (UniProt accession number P02817-2). AMELX isoform 2 (also known as leucine-rich amelogenin peptide (LRAP)) is a naturally occurring isoform of AMELX from the translation product of an alternatively spliced transcript.
