Extended Data Fig. 8: Contribution of mouse FRP1 to plague disease.
a, Serum derived from naive or Y.-pestis-infected Fpr1−/− mice (experiment shown in Fig. 4e) was analysed for IgG specific to capsular fraction 1 antigen (αF1) using ELISA. One of three repeats is shown. Data are mean + s.e.m. (n = 3 biological replicates, shown as circles). b, Representative spleen sections stained with haematoxylin and eosin from naive or Y.-pestis-infected mice shown in Fig. 4e. c, Measurements of white pulp areas in spleens. Each dot represents the average white pulp surface area in each mouse (n = 19–101 per mouse, data quantified using ImageJ). Horizontal bars denote the mean, circles indicate individual values. Significant differences were determined using one-way ANOVA and Bonferroni post hoc analysis (a) and Mann–Whitney and Kruskal–Wallis tests (c). **P < 0.01; *P < 0.05; ns, not significant
