Extended Data Fig. 6: UNC93B1(K333R) confers enhanced TLR7 signalling without affecting TLR9 and TLR3.
From: UNC93B1 recruits syntenin-1 to dampen TLR7 signalling and prevent autoimmunity
Flow cytometry analysis showing the percentage of TNF-positive cells, measured by intracellular cytokine staining of UNC93B1-deficient RAW macrophages expressing the indicated alleles after stimulation with CpG (25 nM), R848 (8 ng ml−1), poly(I:C) (20 µg ml−1), or LPS (10 ng ml−1). Shaded histograms show unstimulated controls. Data are representative of three independent experiments.
