Extended Data Fig. 1: A C-terminal region in UNC93B1 regulates TLR7 responses.
From: UNC93B1 recruits syntenin-1 to dampen TLR7 signalling and prevent autoimmunity
a, UNC93B1PKP-expressing macrophages show enhanced TLR7 signalling. Immunoblot of phosphorylated (P)-p38, P-JNK, P-ERK and IκBα of RAW macrophages stimulated with R848 (50 ng ml−1) for the indicated times. Data are representative of two independent experiments. b, UNC93B1–Flag expression levels, as measured by Flag immunoblot, of UNC93B1-deficient RAW macrophages retrovirally transduced to express the indicated UNC93B1 alleles. Cell lines are as described in Fig. 1a. All data are representative of three independent experiments, unless otherwise noted.
