Extended Data Fig. 1: Ripk4D161N/D161N mice are neonatal lethal.
From: The RIPK4–IRF6 signalling axis safeguards epidermal differentiation and barrier function
a, Organization of the constitutive Ripk4D161N knock-in allele. Boxes represent exons. Untranslated regions are shaded grey. Not to scale. b, Western blots of wild-type, Ripk4+/D161N and Ripk4D161N/D161N E16.5 skin. Representative of three independent experiments. c, Table showing the observed and expected numbers at clipping (P4–P7) of offspring that were generated from intercrossing Ripk4+/D161N mice. d–g, Organization of the conditional Ripk4 knockout allele (d), conditional Irf6 knockout allele (e), constitutive Irf6S413A,S424A knock-in allele (f) and constitutive Irf6S413E,S424E knock-in allele (g). Boxes represent exons. Untranslated regions are shaded grey. Not to scale.
