Extended Data Fig. 1: The hmMHC predictive algorithm and IEDB′18 H2-I-Ab training dataset composition.
From: MHC-II neoantigens shape tumour immunity and response to immunotherapy
a, An example of a fully connected HMM with three hidden states, and emissions corresponding to amino acids. b–d, Composition of IEDB dataset (MHC full ligand export downloaded on 25 November 2018) represented as number of peptides per binding category and measurement type (b, c) and binding category and peptide length (d). Strong binders: IC50 ≤ 50 nM; binders: 50 nM < IC50 ≤ 500 nM; weak binders: 500 nM < IC50 ≤ 5,000 nM; non-binders: all remaining peptides.
