Extended Data Fig. 6: Crypt phylogenies.

a–ap, For each individual, the phylogeny of crypts is shown three times: at the top, with branch lengths proportional to the number of SBSs; in the middle, with branch lengths proportional to the number of DBSs; and on the bottom, with branch lengths proportional to the number of small indels. Scale bars are shown on the right. A stacked bar plot of the mutational signatures that contribute to each branch is overlaid over every branch. ‘X0’ indicates mutations that could not confidently be assigned to any signature. Note that the ordering of signatures along a given branch is just for visualization purposes; we cannot distinguish the timing of different signatures along a branch. aq, The cumulative burden of SBSA (top) and SBSB (bottom) is plotted relative to the cumulative burden of SBS1 to time these mutational processes throughout life. Informative clades are shown (from patients labelled as in the rest of the figure), with every node and tip of the clade plotted in the space of the cumulative number of mutations that are due to a given signature that have occurred up until that node in the tree. Lines represent the branching structure of the tree.