Extended Data Fig. 9: Occurrence matrix of signatures and driver mutations in crypts.

For all crypts that were whole-genome sequenced to sufficient depth, and for crypts that underwent targeted sequencing and in which driver mutations were found, the signatures and driver mutations are shown. Each vertical column represents a crypt. The individual to whom each crypt belongs is indicated by the alternating colours in the top bar (labelling as in Extended Data Fig. 6). The site to which each crypt belongs is shown underneath. The matrix is coloured by the contribution of each signature to each crypt, normalized for each signature: the crypt with the largest contribution of a given signature is purple and the crypt with the smallest contribution is white. Crypts in which the signatures could not be assessed, either because they underwent targeted sequencing or because the coverage was poor, are grey. Driver mutations, including heterozygous mutations in tumour suppressor genes, are indicated by a black bar.