Extended Data Fig. 11: Comparison of the mutational signatures and driver landscape of normal crypts and colorectal adenocarcinomas.

a, Comparison of the burden of mutations for every mutational signature. For each signature, the y axis shows the mutational burden + 1 of every sample on a logarithmic scale. Normal colon and cancer samples are ordered within their groups. The signature attributions and mutational burden for colorectal adenocarcinoma are from a previous study². A total of 60 cancers are compared with 472 normal crypts. b, The proportion of driver mutations in each gene in normal colon (left) and colorectal cancer (right). The frequency of driver mutations in cancer was derived using data from TCGA research network⁴³ (Supplementary Methods).