Extended Data Fig. 3: Decomposition of HDP signatures by expectation maximization.
From: The landscape of somatic mutation in normal colorectal epithelial cells
Three signatures were decomposed (SBS1, DBSA and IDC). For each example, the original HDP version is shown on the top left, the PCAWG signatures that are deemed to contribute at least 10% of mutations to it on the right and the reconstituted signature that was built by combining the PCAWG signatures on the bottom left. The cosine similarity of the reconstituted signature to the original is shown.
