Extended Data Fig. 5: Linear modelling of the accumulation of signatures.
From: The landscape of somatic mutation in normal colorectal epithelial cells
For signatures that appeared to show a linear accumulation with age, the mutation rate per site was determined using mixed models, in which age and site were used as fixed effects and individual as a random effect. Confidence intervals were determined by bootstrapping. n = 445 crypts from 42 individuals. Solid lines represent the mean slope of the regression and shaded areas its 95% confidence intervals (CI95).
