Extended Data Fig. 10: Mechanism of chaperone-controlled regulation of α-synuclein function, conformation and localization in mammalian cells.
From: Regulation of α-synuclein by chaperones in mammalian cells
Cellular chaperones (yellow) interact with the N-terminal segment of α-synuclein (red), thus actively regulating its functional species by shifting conformational equilibria. Impairment of the natural α-synuclein–chaperone ratio or abrogation of the α-synuclein–chaperone interaction by post-translational modifications can lead to the formation of pathological species, including the accumulation of α-synuclein at mitochondria.
