Extended Data Fig. 2: Further behavioural analyses for sociability performance after treatment with LPS in PBS and MIA offspring, and monogenic mutant mice.
From: IL-17a promotes sociability in mouse models of neurodevelopmental disorders
a–d, Time spent investigating social (S) versus inanimate (I) objects (a), total interaction time (b), time spent in social (S), centre (C) or inanimate (I) chamber (c), and distance travelled (d) for sociability experiments in Fig. 1c. PBS offspring + vehicle, n = 10; PBS offspring + LPS, n = 9; MIA offspring + vehicle, n = 10; MIA offspring + LPS, n = 12; wild type (WT) + vehicle, n = 8; wild type + LPS, n = 11; Cntnap2 mutant + vehicle, n = 11; Cntnap2 mutant + LPS, n = 11; Fmr1 mutant + vehicle, n = 11; Fmr1 mutant + LPS, n = 15; Shank3 mutant + vehicle, n = 8; Shank3 mutant + LPS, n = 10; from 3 independent experiments. All n values refer to the number of mice used. Statistics calculated by two-way ANOVA with Sidak’s (a) or Dunnett’s (c) post-hoc test, or two-way repeated-measures ANOVA with Sidak’s post-hoc test (b, d). Graphs are mean ± s.e.m.
