Extended Data Fig. 4: Acute increase in body temperature is insufficient to promote sociability.
From: IL-17a promotes sociability in mouse models of neurodevelopmental disorders
a, Body temperature profile after injection of vehicle or LPS in MIA offspring. Vehicle, n = 10; LPS, n = 10; from 4 independent experiments. The initial spike in body temperature is due to handling stress. b–e, Data are expressed as time spent investigating social (S) versus inanimate (I) objects (b), total interaction time (c), time spent in social (S), centre (C) or inanimate (I) chamber (d), and distance travelled (e) during three-chambered sociability experiments described in Fig. 1g. n = 9 for all groups, from 2 independent experiments. f–j, Sociability performance in Vgat–Cre PBS and MIA offspring after treatment with vehicle, CNO or LPS. Data are expressed as per cent sociability (f), time spent investigating social (S) versus inanimate (I) objects (g), total interaction time (h), time spent in social (S), centre (C) or inanimate (I) chamber (i), and distance travelled (j) during three-chambered sociability experiments. PBS offspring, n = 11; MIA offspring, n = 7; from 2 independent experiments. All n values refer to the number of mice used. Statistics calculated by two-way repeated-measures ANOVA with Bonferroni’s (a) or Dunnett’s (f, h, j) post-hoc tests, two-way ANOVA with Sidak’s (b, g) or Dunnett’s (d, i) post-hoc tests, or one-way repeated-measures ANOVA with Tukey’s post-hoc test (c, e). Graphs are mean ± s.e.m.
