Extended Data Fig. 7: Clonal expansion in UC rectums.
From: Frequent mutations that converge on the NFKBIZ pathway in ulcerative colitis
a, Expansion of clones within the rectum from the remaining four out of the six analysed patients with UC (two are presented in Fig. 2d). All of the representations follow those in Fig. 2d. Driver mutations including those found in the two samples in Fig. 2d are summarized in Supplementary Table 9. b, Area occupied by each clone and total number of mutations estimated by PyClone for each clone detected in the UC rectums. Colours indicate the highest pathological grade within each clone. c–h, Phylogenetic trees of representative clones (6 out of 41) that were found in two or more rectum samples surgically obtained from six patients with UC. Imputed clonal structures are depicted in violin plots at the bottom, in which the estimated cellular prevalence of imputed mutational clusters (x axis) are shown as the distribution of posterior probabilities (width of the violin plots) calculated according to a PyClone model. Colours correspond to those in the associated branches of trees. The estimated time of UC onset is indicated on the basis of the mutation rate in non-UC crypts (Fig. 1a). Branches that contain driver mutations are also indicated.
