Extended Data Fig. 5: Phenotype of other induced CSPs to a panel of insecticides.
From: A sensory appendage protein protects malaria vectors from pyrethroids
a, Effect of attenuation of dsSAP3 on mortality after insecticide exposure in Tiassalé mosquitoes (right bars; deltamethrin, n = 4; permethrin, n = 5; α-cypermethrin, n = 3; DDT, n = 3; pirimiphos-methyl, n = 3; bendiocarb, n = 4) compared with dsGFP-injected controls (left bars, green patterned; deltamethrin, n = 5; permethrin, n = 5; α-cypermethrin, n = 5; DDT, n = 4; pirimiphos-methyl, n = 4; bendiocarb, n = 8). b, Effect of attenuation of dsCSP4 on mortality after insecticide exposure in Tiassalé mosquitoes (right bars; deltamethrin, n = 3; permethrin, n = 3; α-cypermethrin, n = 3; DDT, n = 3; pirimiphos-methyl, n = 3; bendiocarb, n = 3) compared with dsGFP-injected controls (left bars, green patterned; deltamethrin, n = 5; permethrin, n = 5; α-cypermethrin, n = 5; DDT, n = 4; pirimiphos-methyl, n = 4; bendiocarb, n = 8). c, Effect of attenuation of dsCSP6 on mortality after insecticide exposure in Tiassalé mosquitoes (right bars; deltamethrin, n = 6; permethrin, n = 4; α-cypermethrin, n = 4; DDT, n = 3; pirimiphos-methyl, n = 4; bendiocarb, n = 5) compared with dsGFP-injected controls (left bars, green patterned; deltamethrin, n = 5; permethrin, n = 5; α-cypermethrin, n = 5; DDT, n = 4; pirimiphos-methyl, n = 4; bendiocarb, n = 8). Analysis of mortality data was done using an ANOVA followed by a Tukey post hoc test; n.s indicates a non-significant change in mortality; *P ≤ 0.05. dsCSP6 μmortality = 11.7–31.6%, P = 0.0474. N indicates the number of individual mosquitoes used for phenotyping; points show the number of bioassay replicates per group. Data are mean ± s.d.
