Extended Data Fig. 8: Comparison of RORγ+ Treg cell signature genes of colonic Treg cells from Vdr+/+ and Vdr−/− mice.
From: Microbial bile acid metabolites modulate gut RORγ+ regulatory T cell homeostasis
Volcano plots comparing transcriptomes of colonic Treg cells from Vdr+/+Foxp3mRFP and Vdr−/−Foxp3mRFP mice (n = 3). Colonic RORγ+ Treg cell signature genes are highlighted in red (upregulated) or blue (downregulated). The number of genes from each signature preferentially expressed by one or the other population is shown at the bottom. Data are pooled from two independent experiments. n represents biologically independent animals. To determine the enrichment of certain gene signatures in RNA-seq datasets, a χ2 test was used. P < 0.05 was considered statistically significant.
