Extended Data Fig. 7: Sequential inactivation of cortex and thalamus.
From: Cortical pattern generation during dexterous movement is input-driven
a, Fraction of trials with lifts in each epoch for control trials (yellow), cortical inactivation only (blue) and sequential inactivation of cortex and thalamus (green) (n = 3 mice, n = 4 sessions). The cortical inactivation ends at 2,000 ms from the start of the trial, and the thalamic inactivation ends at 4,000 ms. Bars show maximum likelihood estimates of the binomial probability, with 95% confidence intervals. Corresponding data in Fig. 3d–f. b, Lift-locked neural population activity from lift −100 ms to lift +350 ms for control (yellow), post-cortex-inactivation (blue) and post-sequential-inactivation reaches (green), obtained using trial-averaged PCA; n = 3 mice, n = 4 sessions, n = 127 neurons. Circles indicate lift −100 ms, lift and grab times. c, Firing rates and spike rasters for an example cortical neuron on control trials (yellow), cortical inactivation (blue) and sequential inactivation of cortex and thalamus (green).
