Extended Data Fig. 4: Cryo-EM density supports ligand interactions in the TT-OAD2-binding site.
From: Activation of the GLP-1 receptor by a non-peptidic agonist
a, Interacting residues predicted by LigPlot using the full-length model with ECD. b, The pose of TT-OAD2 and interactions with residues within TM1, TM2, TM3, ECL1 and ECL2 are supported by well-resolved density in the cryo-EM map. c, Density for the ECD was visible in the cryo-EM and supports extended interactions of the ECD with ECL1 and ECL2, as well as with the ligand TT-OAD2.
