Extended Data Fig. 5: Structure of SIRV1 gp29 bound to cA4.
From: An anti-CRISPR viral ring nuclease subverts type III CRISPR immunity
a, b, Orthogonal views of SIRV1 gp29 dimer in complex with cA4. The protein monomers are coloured purple and gold, with catalytic residue H47 from the apo structure shown in salmon. cA4 is shown as a spacefill model, with green, blue, red and orange representing carbon, nitrogen, oxygen and phosphorus atoms, respectively. Conserved residues (Extended Data Fig. 1) in the AcrIII-1 family are indicated and discussed in the text. c, Interactions between each monomer of the SIRV1 dimer (orange and blue), with cA4 shown in green. d, Diagram showing the interaction between SIRV1 gp29 and cA4. Dotted lines represent hydrogen bonds, with distances annotated. Spheres represent water molecules.
