Extended Data Fig. 6: Schematic view of how LMP1 signalling in B cells induces cytotoxic CD4 and CD8 T cell responses to TAAs. | Nature

Extended Data Fig. 6: Schematic view of how LMP1 signalling in B cells induces cytotoxic CD4 and CD8 T cell responses to TAAs.

From: Mechanism of EBV inducing anti-tumour immunity and its therapeutic use

Extended Data Fig. 6: Schematic view of how LMP1 signalling in B cells induces cytotoxic CD4 and CD8 T cell responses to TAAs.The alternative text for this image may have been generated using AI.

LMP1 signalling in B cells induces massive cellular gene expression. This leads to (1) upregulation of cellular machinery involved in antigen processing and presentation, (2) upregulation of costimulatory ligands (CD70, OX40L and others), and (3) overexpression of many cellular antigens known as TAAs. Presentation of the LMP1-induced cellular antigens/TAAs and simultaneous costimulation through CD70 and OX40L drive cytotoxic CD4 and CD8 T cell responses.

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